These data show the latest WHO/UNICEF Estimates of National Immunization Coverage (WUENIC) for the WHO Region of the Americas. They are based on data reported until 7 July 2022. WUENIC estimates include a Grade of Confidence assigned to each estimated data point. The current release of the WUENIC with data up to 2021 (released in 2022) includes estimates for WHO Member States, including those that did not report 2021 data. For these non-reporting countries, estimates were extrapolated from the last point informed by empirical data. Similarly, global and regional coverages, values were extrapolated from 2020 for non-reporting countries. Non-reporting countries represent ≈6% of the global 2021 cohort. WUENIC data time series are updated annually in July based on available reported data and survey results. Coverage data can help to identify gaps, and can be viewed globally, regionally, or at the country level by selecting an antigen to view the coverage data time series.